Publikationen

Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid

Autor(en)
Denise-Silvia Mahrhauser, Hanspeter Kählig, Ewa Partyka-Jankowska, Herwig Peterlik, Lisa Binder, Kristina Kwizda, Claudia Valenta
Abstrakt

Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active components. Therefore, this study aimed to characterize fluorosurfactant-based microemulsions and to assess the impact of formulation variables on the transdermal delivery of incorporated flufenamic acid. The microemulsion systems prepared in this study consisted of bistilled water, oleic acid, isopropanol as co-solvent, flufenamic acid as active ingredient and either Hexafor (TM) 670 (Hex) or Chemguard S-550-100 (Sin) as fluorosurfactant. Characterization was performed by a combination of techniques including electrical conductivity measurements, small-angle X-ray scattering (SAXS) and nuclear magnetic resonance (NMR) self-diffusion experiments. In vitro skin permeation experiments were performed with each prepared microemulsion using Franz type diffusion cells to correlate their present microstructure with their drug delivery to skin. Electrical conductivity increased with added water content. Consequently, the absence of a conductivity maximum as well as the NMR and SAXS data rather suggest O/W type microemulsions with spherical or rod-like microstructures. Skin permeation data revealed enhanced diffusion for Hex- and Sin-microemulsions if the shape of the structures was rather elongated than spherical implying that the shape of droplets had an essential impact on the skin permeation of flufenamic acid. (C) 2015 Elsevier B.V. All rights reserved.

Organisation(en)
Department für Pharmazeutische Technologie und Biopharmazie, Forschungsplattform Characterisation of Drug Involved Mechanisms, NMR Zentrum, Institut für Organische Chemie, Dynamik Kondensierter Systeme
Journal
International Journal of Pharmaceutics
Band
490
Seiten
292-297
Anzahl der Seiten
6
ISSN
0378-5173
DOI
https://doi.org/10.1016/j.ijpharm.2015.05.056
Publikationsdatum
07-2015
Peer-reviewed
Ja
ÖFOS 2012
301207 Pharmazeutische Chemie
Schlagwörter
Link zum Portal
https://ucris.univie.ac.at/portal/de/publications/investigation-of-microemulsion-microstructure-and-its-impact-on-skin-delivery-of-flufenamic-acid(b2e1a673-4cbd-4347-bc7e-647611bf8fcc).html