Publications

Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid

Author(s)
Denise-Silvia Mahrhauser, Hanspeter Kählig, Ewa Partyka-Jankowska, Herwig Peterlik, Lisa Binder, Kristina Kwizda, Claudia Valenta
Abstract

Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active components. Therefore, this study aimed to characterize fluorosurfactant-based microemulsions and to assess the impact of formulation variables on the transdermal delivery of incorporated flufenamic acid. The microemulsion systems prepared in this study consisted of bistilled water, oleic acid, isopropanol as co-solvent, flufenamic acid as active ingredient and either Hexafor

670 (Hex) or Chemguard S-550-100 (Sin) as fluorosurfactant. Characterization was performed by a combination of techniques including electrical conductivity measurements, small-angle X-ray scattering (SAXS) and nuclear magnetic resonance (NMR) self-diffusion experiments. In vitro skin permeation experiments were performed with each prepared microemulsion using Franz type diffusion cells to correlate their present microstructure with their drug deliverytoskin. Electrical conductivity increased with added water content. Consequently, the absence of a conductivity maximum as well as the NMR and SAXS data rather suggest O/W type microemulsions with spherical or rod-like microstructures. Skin permeation data revealed enhanced diffusion for Hexand Sin-microemulsions if the shape of the structures was rather elongated than spherical implying that the shape of droplets had an essential impact on the skin permeation of flufenamic acid.

Organisation(s)
NMR Centre, Department of Organic Chemistry, Dynamics of Condensed Systems
External organisation(s)
Universität Wien
Journal
International Journal of Pharmaceutics
Volume
490
Pages
292-297
No. of pages
6
ISSN
0378-5173
DOI
https://doi.org/10.1016/j.ijpharm.2015.05.056
Publication date
07-2015
Peer reviewed
Yes
Austrian Fields of Science 2012
301207 Pharmaceutical chemistry
Keywords
ASJC Scopus subject areas
Pharmaceutical Science
Portal url
https://ucris.univie.ac.at/portal/en/publications/investigation-of-microemulsion-microstructure-and-its-impact-on-skin-delivery-of-flufenamic-acid(b2e1a673-4cbd-4347-bc7e-647611bf8fcc).html